It’s one thing to be excited about resveratrol and the benefits it has for improving your health and lifespan, but there is obviously more to it when it comes to choosing the product that is most likely to deliver the resveratrol in a way your body can absorb. Definitely something to consider.
Resveratrol – Bioavailability and Metabolization
Resveratrol is a very volatile molecule and when exposed to oxygen, oxidizes and breaks down rapidly.
It is thus important for manufacturers to produce the Resveratrol supplements in an environment that preserves its potency. In addition, the delivery mechanism is very important as it will determine both the bioavailability of the Resveratrol content as well as the metabolization.
Data concerning the bioavailability of resveratrol in people is necessary and crucial since most of the studies on resveratrol have been done on cultured cells in pietre dishes in the lab which are exposed to resveratrol which has been unmatabolized and in concentrations that are usually ten to a hundred times in excess of the highest concentrations measured in human plasma after been orally consumed. Even though the digestive tract cells are exposed to unmetabolized resveratrol, research in humans suggests that other organs and cellular tissues are exposed mainly to metabolized resveratrol. Not much is understood about the biological activity of metabolized resveratrol , and it has not been conclusively determined if some cells are able to convert resveratrol metabolites back to resveratrol.
Therefore, ingesting resveratrol supplements that deliver a more effective bioactive resveratrol dose is an important factor in the manufacturing of these resveratrol products. There are several methods being utilized by the major resveratrol manufacturers to improve bioavailability.
One of the main strategies is the encapsulation process of resveratrol. Not only is it critical to process resveratrol in a nitrogen enviroment – free of oxygen – to avoid the rapid breakdown from oxidation, it is equally important to seal the contents in an airtight capsule that prevents disintegration of the molecule once packaged. That is why sealed capsules are preferable over tablet or powder forms. Some companies even produce an encapsulated resveratrol supplement in a liquid form as well because it is easier to absorb than powder forms (Resvantage Brand).
Another prominent strategy to increase the bioactive nature of the supplement is called micronization. This is a process where fine grinding mills – either jar mills or fluid energy mills – are used to reduce powder forms of Resveratrol or any other supplement into a smaller size(typically under 10 microns) particle that has been demonstrated to be more readily absorbed in the blood stream (Revgenetics Brand).
Finally, taking a liquid Resveratrol dose sublingually(under the tongue) may end up being the most effective method of taking Resveratrol because it is so easily absorbed and avoids the potential breakdown and disposal from the digestive process. There are a few manufacturers offering beverage dietary supplements which include Resveratrol.(Resversitall Plus by Neocell) Just like swirling a gulp of red wine around in your mouth, this approach may improve the amount of bioactive Resveratrol making into the body’s cells and organs.
More research into the delivery of the Resveratrol molecule will likely lead to improved methods of augmenting bioavailability. At present, the more attention paid to the manufacturing process and delivery of resveratrol, the more impactful the dose will be and the lower the dosage requirements will be needed because absorption will be much higher.
Original article here
